phenobarbital will decrease the level or outcome of alfentanil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unknown.

phenobarbital will minimize the extent or effect of diclofenac by affecting hepatic enzyme CYP2C9/ten metabolism. Insignificant/Importance Unknown.

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phenobarbital will decrease the level or outcome of rolapitant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Long-expression coadministration of strong CYP3A4 inducers with rolapitant may perhaps substantially decrease rolapitant efficacy.

phenobarbital will reduce the level or outcome of lumefantrine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with robust CYP3A4 inducers may lead to reduced serum concentrations and loss of antimalarial efficacy

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Animal Information. Phenobarbital sodium is carcinogenic in mice and rats after lifetime administration. In mice, it developed benign and malignant liver mobile tumors. In rats, benign liver cell tumors were noticed quite late in life.

phenobarbital and olopatadine intranasal both of those raise sedation. Avoid or Use Alternate Drug. Coadministration boosts threat of CNS melancholy, which may lead to additive impairment of psychomotor general performance and result in daytime impairment.

phenobarbital will lessen the level or effect of brivaracetam by influencing hepatic enzyme CYP2C19 metabolism. Use Caution/Monitor. Brivaracetam plasma focus lowered by 19%.

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phenobarbital will reduce the level or effect of ethinylestradiol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. The efficacy of hormonal contraceptives may be minimized. Utilization of a nonhormonal contraceptive is suggested.

No information is available on the connection of age to the consequences of phenobarbital injection in geriatric people.

It is a non-sterile Alternative containing pentobarbital sodium and phenytoin sodium as the Energetic more info ingredients. Readily available in 100 mL numerous-dose vials, Every single mL consists of 390 mg pentobarbital sodium and fifty mg phenytoin sodium. Rhodamine B, a bluish-crimson fluorescent dye, is included in the formulation to help distinguish it from parenteral medications supposed for therapeutic use.

phenobarbital will decrease the extent or result of doravirine by affecting hepatic/intestinal enzyme CYP3A4 metabolism.